Gainesville may not be one of Florida's top tourist hubs, as it's nowhere near any beaches, but this generally progressive college town in the state's north-central region does have a good-size GLBT population and a terrific, centrally located gay nightclub, the University Club (18 E. University Ave., 352-378-6814), which is steps from a number of cool cafes, restaurants, and indie shops in the city's bustling downtown. The club draws a mix of gay men and women, plus quite a few heteros depending on the night, and is a top pick for dancing and socializing. There are multiple bars as well as a good size outdoor area. Check out the club's website for information on upcoming events and parties. Note that you enter the University Club via the door in the back of the building, just off of Northeast 1st Avenue.
You'll find one other gay bar in Gainesville, Wild Angels-Spikes (4130 N.W. 6th St., 352-376-3772), which is a short drive north of downtown is typically caters to more of an over-40 set, including bears, fans of leather, and the like. But this somewhat more male-oriented club does get its share of younger guys, too, and is very welcoming to women. Drinks here are well-priced, and the bar hosts some drag shows on occasion. Here's the Facebook page for Wild Angels-Spikes, with a bit more information, plus photos posted by customers.
Gainesville is in north-central Florida, about a 90-minute drive southwest of Jacksonville, two-hour drive north of Orlando and Disney, a 2- to 2.5-hour drive northeast of St. Petersburg and Tampa, and a 2.5-hour drive east of Tallahassee.